Accelerated epigenetic aging in Down syndrome

Aging Cell

Steve Horvath³  Paolo Garagnani²  Maria Giulia Bacalini²  Chiara Pirazzini²  Stefano Salvioli²  Davide Gentilini¹  Anna Maria Di Blasio¹  Cristina Giuliani⁵  Spencer Tung⁴  Harry V. Vinters⁴ 

[1] Center of Research and Biomedical Technology, Istituto Auxologico Italiano IRCCS, Cusano Milanino, Milan, Italy;Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy;Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA;Department of Neurology and Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA;Department of Biological, Geological and Environmental Sciences, University of Bologna, Bologna, Italy

关键词: biomarker of aging;    DNA methylation;    Down syndrome;    epigenetics;   

DOI  :  10.1111/acel.12325

来源: Wiley

【 摘 要 】

Summary

Down Syndrome (DS) entails an increased risk of many chronic diseases that are typically associated with older age. The clinical manifestations of accelerated aging suggest that trisomy 21 increases the biological age of tissues, but molecular evidence for this hypothesis has been sparse. Here, we utilize a quantitative molecular marker of aging (known as the epigenetic clock) to demonstrate that trisomy 21 significantly increases the age of blood and brain tissue (on average by 6.6 years, P = 7.0 × 10⁻¹⁴).

【 授权许可】

CC BY   
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.