Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human

Aging Cell

Sheila L. MacRae³  Quanwei Zhang⁴  Christophe Lemetre⁴  Inge Seim²  Robert B. Calder⁴  Jan Hoeijmakers¹  Yousin Suh⁴  Vadim N. Gladyshev²  Andrei Seluanov⁵  Vera Gorbunova⁵  Jan Vijg⁴ 

[1] Department of Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands;Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA;ORCID:orcid.org/0000-0002-0150-2294;Department of Genetics, Albert Einstein College of Medicine, Bronx, NY, USA;Department of Biology, University of Rochester, Rochester, NY, USA

关键词: aging;    gene duplication;    genome maintenance;    longevity;    mutation rate;   

DOI  :  10.1111/acel.12314

来源: Wiley

【 摘 要 】

Summary

Genome maintenance (GM) is an essential defense system against aging and cancer, as both are characterized by increased genome instability. Here, we compared the copy number variation and mutation rate of 518 GM-associated genes in the naked mole rat (NMR), mouse, and human genomes. GM genes appeared to be strongly conserved, with copy number variation in only four genes. Interestingly, we found NMR to have a higher copy number of CEBPG, a regulator of DNA repair, and TINF2, a protector of telomere integrity. NMR, as well as human, was also found to have a lower rate of germline nucleotide substitution than the mouse. Together, the data suggest that the long-lived NMR, as well as human, has more robust GM than mouse and identifies new targets for the analysis of the exceptional longevity of the NMR.

【 授权许可】

CC BY   
© 2015 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.