The rejuvenating effect of pregnancy on muscle regeneration

Aging Cell

Tal Falick Michaeli¹  Neri Laufer⁴  Jitka Yehudit Sagiv¹  Avigail Dreazen²  Zvi Granot¹  Eli Pikarsky³  Yehudit Bergman¹ 

[1] Rubin Chair in Medical Science, Department of Developmental Biology & Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel;Department of Biochemistry & Molecular Biology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel;Department of Pathology & the Lautenberg Center for Immunology, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel;Department of Obstetrics & Gynecology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

关键词: aging;    muscle;    pregnancy;    regeneration;    rejuvenation;   

DOI  :  10.1111/acel.12286

来源: Wiley

【 摘 要 】

Summary

Aging is characterized by reduced tissue regenerative capacity attributed to a diminished responsiveness of tissue-specific stem cells. With increasing age, resident precursor cells in muscle tissues show a markedly impaired propensity to proliferate in response to damage. However, exposure to factors present in the serum of young mice restores the regenerative capacity of aged precursor cells. As pregnancy represents a unique biological model of a partially shared blood system between young and old organisms, we hypothesized that pregnancy in aged mice would have a rejuvenating effect on the mother. To test this hypothesis, we assessed muscle regeneration in response to injury in young and aged pregnant and nonpregnant mice. Muscle regeneration in the aged pregnant mice was improved relative to that in age-matched nonpregnant mice. The beneficial effect of pregnancy was transient, lasting up to 2 months after delivery, and appeared to be attributable to activation of satellite cells via the Notch signaling pathway, thus supporting the possibility that pregnancy induces activation of aged dormant muscle progenitor cells.

【 授权许可】

CC BY   
© 2014 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.