Ambulant 24‐h glucose rhythms mark calendar and biological age in apparently healthy individuals

Aging Cell

Carolien A. Wijsman⁴  Diana van Heemst⁴  Evelien S. Hoogeveen⁴  P. Eline Slagboom³  Andrea B. Maier⁴  Anton J. M. de Craen⁴  Frans van der Ouderaa²  Hanno Pijl¹  Rudi G. J. Westendorp⁴ 

[1] Department of Endocrinology, Leiden University Medical Center, Leiden, RC, The Netherlands;Netherlands Consortium for Healthy Ageing, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands;Department of Medical Statistics, Section of Molecular Epidemiology, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands;Department of Gerontology and Geriatrics, Leiden University Medical Center, 2300 RC, Leiden, The Netherlands

关键词: aging;    continuous glucose monitoring;    endocrinology;    Glucose metabolism;    human;    longevity;   

DOI  :  10.1111/acel.12042

来源: Wiley

【 摘 要 】

Abstract

Glucose metabolism marks health and disease and is causally inferred in the aging process. Ambulant continuous glucose monitoring provides 24-h glucose rhythms under daily life conditions. We aimed to describe ambulant 24-h glucose rhythms measured under daily life condition in relation to calendar and biological age in apparently healthy individuals. In the general population and families with propensity for longevity, we studied parameters from 24-h glucose rhythms; glucose levels; and its variability, obtained by continuous glucose monitoring. Participants were 21 young (aged 22–37 years), 37 middle-aged (aged 44–72 years) individuals from the general population, and 26 middle-aged (aged 52–74 years) individuals with propensity for longevity. All were free of diabetes. Compared with young individuals, middle-aged individuals from the general population had higher mean glucose levels (5.3 vs. 4.7 mmol L⁻¹, P < 0.001), both diurnally (P < 0.001) and nocturnally (P = 0.002). Glucose variability was higher in the middle-aged compared with the young (standard deviation 0.70 vs. 0.57 mmol L⁻¹, P = 0.025). Compared with middle-aged individuals from the general population, middle-aged individuals with propensity for longevity had lower overall mean glucose levels (5.2 vs. 5.4 mmol L⁻¹, P = 0.047), which were more different nocturnally (4.8 vs. 5.2 mmol L⁻¹, P = 0.003) than diurnally (5.3 vs. 5.5 mmol L⁻¹, P = 0.14). There were no differences in glucose variability between these groups. Results were independent of body mass index. Among individuals without diabetes, we observed significantly different 24-h glucose rhythms depending on calendar and biological age.

【 授权许可】

Unknown   
© 2012 The Authors Aging Cell © 2012 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland