Review: The Emerging Role of Neutrophil Extracellular Traps in Sepsis and Sepsis-Associated Thrombosis

Frontiers in Cellular and Infection Microbiology

Hanzhong Cao¹  Juan P. Cata²  Hao Zhang³  Ke Nan³  Changhong Miao³  Zhaoyuan Chen³  Mengdi Qu³  Wankun Chen⁴ 

[1] Anesthesiology and Surgical Oncology Research Group, Department of Anesthesiology and Perioperative Medicine, Nantong, China;Department of Anesthesiology and Perioperative Medicine, Anesthesiology and Surgical Oncology Research Group, The University of Texas MD Anderson Cancer Center, Houston, TX, United States;Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China;Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China;Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai, China;Cancer Center, Zhongshan Hospital, Fudan University, Shanghai, China;Zhangjiang Institute, Fudan University, Shanghai, China;

关键词: sepsis;    thrombosis;    neutrophil extracellular traps;    platelets;    complement;   

DOI  :  10.3389/fcimb.2021.653228

来源: Frontiers

【 摘 要 】

Patients with sepsis commonly suffer from coagulation dysfunction and lead to the formation of thrombus. During the development of sepsis, neutrophils migrate from the circulating blood to infected tissues and mediate the formation of neutrophil extracellular traps (NETs) that kill pathogens. However, the overactivation of neutrophils can promote the formation of immunothrombosis and even cause disseminated intravascular coagulation (DIC), which damages microcirculation. The outcome of sepsis depends on early recognition and intervention, so clinical evaluation of NETs function may be a valuable biomarker for early diagnosis of sepsis. The interaction of NETs with platelets, complement, and endothelium mediates the formation of immunothrombosis in sepsis. Inhibiting the formation of NETs is also considered to be one of the potential treatments for sepsis. In this review, we will discuss the key role of neutrophils and NETs in sepsis and septic thrombosis, in order to reveal new mechanisms for thrombosis treatment of sepsis.

【 授权许可】

CC BY