Translational Potential of Epigenetic-Based Markers on Fine-Needle Aspiration Thyroid Specimens

Frontiers in Medicine

Mafalda Pinto¹  Sule Canberk²  Ana Rita Lima³  Valdemar Máximo⁴ 

[1] Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal;Cancer Signalling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal;Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal;Cancer Signalling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal;Abel Salazar Institute of Biomedical Sciences (ICBAS), University of Porto, Porto, Portugal;Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal;Cancer Signalling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal;Faculty of Medicine of the University of Porto (FMUP), Alameda Prof. Hernâni Monteiro, Porto, Portugal;Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Porto, Portugal;Cancer Signalling and Metabolism Group, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Porto, Portugal;Faculty of Medicine of the University of Porto (FMUP), Alameda Prof. Hernâni Monteiro, Porto, Portugal;Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Alameda Prof. Hernâni Monteiro, Porto, Portugal;

关键词: epigenetics;    epigenomics;    thyroid tumor;    thyroid cancer;    thyroid fine needle aspiration;    epigenetic markers of thyroid;   

DOI  :  10.3389/fmed.2021.640460

来源: Frontiers

【 摘 要 】

The awareness of epigenetic alterations leading to neoplasia attracted the attention of researchers toward its potential use in the management of cancer, from diagnosis to prognosis and prediction of response to therapies. Our group has focused its attention on the epigenomics of thyroid neoplasms. Although most of the epigenetic studies have been applied on histological samples, the fact is that cytology, through fine-needle aspiration, is a primary diagnostic method for many pathologies, of which thyroid nodules are one of the most paradigmatic examples. This has led to an increasing literature report of epigenetic studies using these biological samples over the past decade. In this review, our group aimed to document recent research of epigenetic alterations and its associated assessment techniques, based on cytology material. Our review covers the main epigenetic categories—DNA methylation, histone modification, and RNA-silencing—whose evidence in thyroid cytology samples may represent solid soil for future prospectively designed studies aiming at validating patterns of epigenetic alterations and their potential use in the clinical management of thyroid neoplasms.

【 授权许可】

CC BY