Microbiome, Immunosenescence, and Chronic Kidney Disease

Frontiers in Medicine

Elisavet Stavropoulou¹  Theocharis Konstantinidis²  Chrysa Voidarou³  Eugenia Bezirtzoglou⁴  Christina Tsigalou⁵  Mariana Carmen Chifiriuc⁶  Konstantina Aftzoglou⁷  Elias Thodis⁸  Konstantia Kantartzi⁸ 

[1] CHUV (Centre Hospitalier Universitaire Vaudois), Rue du Bugnon, Lausanne, Switzerland;Department of Infectious Diseases, Central Institute, Valais Hospital, Sion, Switzerland;Department of Medicine, Democritus University of Thrace, Alexandroupoli, Greece;Department of Public Health P.U., Arta, Greece;Laboratory of Hygiene and Environmental Protection, Department of Medicine, Democritus University of Thrace, Alexandroupoli, Greece;Laboratory of Microbiology, Department of Medicine, Democritus University of Thrace, Alexandroupoli, Greece;Laboratory of Microbiology, Faculty of Biology, The Research Institute of the University of Bucharest (ICUB), University of Bucharest, Bucharest, Romania;Medical School, Comenius University, Bratislava, Slovakia;Nephrology Clinic, Department of Medicine, Democritus University of Thrace, Alexandroupoli, Greece;

关键词: gut;    kidney;    gut-kidney axis;    microbiome;    ageing;    immunosenescence;    chronic kidney disease;    microbiota;   

DOI  :  10.3389/fmed.2021.661203

来源: Frontiers

【 摘 要 】

The gut microbiome is known as an important predictive tool for perceiving characteristic shifts in disease states. Multiple renal diseases and pathologies seem to be associated with gut dysbiosis which directly affects host homeostasis. The gastrointestinal-kidney dialogue confers interesting information about the pathogenesis of multiple kidney diseases. Moreover, aging is followed by specific shifts in the human microbiome, and gradual elimination of physiological functions predisposes the microbiome to inflammaging, sarcopenia, and disease. Aging is characterized by a microbiota with an abundance of disease-associated pathobionts. Multiple factors such as the immune system, environment, medication, diet, and genetic endowment are involved in determining the age of the microbiome in health and disease. Our present review promotes recently acquired knowledge and is expected to inspire researchers to advance studies and investigations on the involved pathways of the gut microbiota and kidney axis.

【 授权许可】

CC BY