Red Blood Cell Contribution to Hemostasis

Frontiers in Pediatrics

Allan Doctor¹  Andrea H. Gillespie² 

[1] Division of Pediatric Critical Care Medicine, The Center for Blood Oxygen Transport and Hemostasis, University of Maryland School of Medicine, Baltimore, MD, United States;Division of Pediatric Hematology and Oncology, Oregon Health and Sciences University, Portland, OR, United States;

关键词: red blood cell(s);    shear rate;    aggregation;    phosphatidylserine;    microparticles;    hemostasis;   

DOI  :  10.3389/fped.2021.629824

来源: Frontiers

【 摘 要 】

Red Blood Cells (RBCs) have been increasingly recognized to play important roles in hemostasis and the mechanisms by which they do so continue to be elucidated. First and foremost, RBC biomechanics are the principal determinant of viscosity and flow dynamics of blood, which strongly influence all features of hemostasis. Of note, morphologic pathology, such as that found in sickle cell disease, leads to increased risk of thrombotic disease. RBC surface interactions govern signaling between platelets and RBCs and also aid in the conversion of prothrombin to thrombin. Additionally, RBCs generate microparticles which have been shown to reduce clotting time. Finally, blood clot structure and maturation are dependent on the inclusion of RBCs in forming thrombi. Here, we review the above mechanisms of RBC contribution to hemostasis.

【 授权许可】

CC BY