Investigating Pregnancy and Its Complications Using Circulating Cell-Free RNA in Women's Blood During Gestation

Frontiers in Pediatrics

Ronald J. Wong¹  David K. Stevenson¹  Gary M. Shaw¹  Mira N. Moufarrej²  Stephen R. Quake² 

[1] Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States;Departments of Bioengineering and Applied Physics, Stanford University, and Chan Zuckerberg Biohub, Stanford, CA, United States;

关键词: transcriptome;    cell-free RNA;    preeclampsia;    prediction;    preterm birth;    IUGR;   

DOI  :  10.3389/fped.2020.605219

来源: Frontiers

【 摘 要 】

In recent years, there have been major advances in the application of non-invasive techniques to predict pregnancy-related complications, for example by measuring cell-free RNA (cfRNA) in maternal blood. In contrast to cell-free DNA (cfDNA), which is already in clinical use to diagnose fetal aneuploidy, circulating RNA levels can correspond with tissue-specific gene expression and provide a snapshot of prenatal health across gestation. Here, we review the physiologic origins of cfRNA and its novel applications and corresponding challenges to monitor fetal and maternal health and predict pregnancy-related complications.

【 授权许可】

CC BY