Applications of Engineering Techniques in Microvasculature Design

Frontiers in Cardiovascular Medicine

Miao Zhang¹  Aleen Al Halawani²  Linyang Liu²  Ziyu Wang²  Anthony S. Weiss³ 

[1] Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia;School of Biomedical Engineering, University of Sydney, Sydney, NSW, Australia;School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia;Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia;School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia;Charles Perkins Centre, University of Sydney, Sydney, NSW, Australia;Sydney Nano Institute, University of Sydney, Sydney, NSW, Australia;

关键词: microvasculature;    extracellular matrix;    bioprinting;    micropatterning;    porous scaffolds;    vascularized organoids;    elastin;    tropoelastin;   

DOI  :  10.3389/fcvm.2021.660958

来源: Frontiers

【 摘 要 】

Achieving successful microcirculation in tissue engineered constructs in vitro and in vivo remains a challenge. Engineered tissue must be vascularized in vitro for successful inosculation post-implantation to allow instantaneous perfusion. To achieve this, most engineering techniques rely on engineering channels or pores for guiding angiogenesis and capillary tube formation. However, the chosen materials should also exhibit properties resembling the native extracellular matrix (ECM) in providing mechanical and molecular cues for endothelial cells. This review addresses techniques that can be used in conjunction with matrix-mimicking materials to further advance microvasculature design. These include electrospinning, micropatterning and bioprinting. Other techniques implemented for vascularizing organoids are also considered for their potential to expand on these approaches.

【 授权许可】

CC BY