Long Noncoding RNA: Regulatory Mechanisms and Therapeutic Potential in Sepsis

Frontiers in Cellular and Infection Microbiology

Ri Wen¹  Chun-Feng Liu¹  Wei Wang¹  Ni Yang¹  Tie-Ning Zhang¹ 

[1] Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China;

关键词: lncRNA;    sepsis;    biomarker;    inflammation;    cardiovascular dysfunction;    acute lung injury;    acute kidney injury;   

DOI  :  10.3389/fcimb.2021.563126

来源: Frontiers

【 摘 要 】

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is characterized by a hyperinflammatory state accompanied by immunosuppression. Long noncoding RNAs (lncRNAs) are noncoding RNAs longer than 200 nucleotides and have important roles in mediating various biological processes. Recently, lncRNAs were found to exert both promotive and inhibitory immune functions in sepsis, thus participating in sepsis regulation. Additionally, several studies have revealed that lncRNAs are involved in sepsis-induced organ dysfunctions, including cardiovascular dysfunction, acute lung injury, and acute kidney injury. Considering the lack of effective biomarkers for early identification and specific treatment for sepsis, lncRNAs may be promising biomarkers and even targets for sepsis therapies. This review systematically highlights the recent advances regarding the roles of lncRNAs in sepsis and sheds light on their use as potential biomarkers and treatment targets for sepsis.

【 授权许可】

CC BY