Novel Approaches in Cardiac Imaging for Non-invasive Assessment of Left Heart Myocardial Fibrosis

Frontiers in Cardiovascular Medicine

Ciro Santoro¹  Oreste De Vivo²  Flavio D'Ascenzi²  Maria Concetta Pastore²  Nicolò Sisti²  Luna Cavigli²  Giulia Elena Mandoli²  Sergio Mondillo²  Marta Focardi²  Matteo Cameli²  Fabrizio Ricci³  Giovanni Benfari⁴  Giulia Vinco⁴ 

[1] Department of Advanced Biomedical Science, Federico II University Hospital Naples, Naples, Italy;Department of Medical Biotechnologies, Division of Cardiology, University of Siena, Siena, Italy;Department of Neuroscience, Imaging and Clinical Sciences, Institute of Advanced Biomedical Technologies, “G.d'Annunzio” University of Chieti-Pescara, Chieti, Italy;Department of Clinical Sciences, Lund University, Malmö, Sweden;Casa di Cura Villa Serena, Città Sant'Angelo, Italy;Section of Cardiology, Department of Medicine, University of Verona, Verona, Italy;

关键词: fibrosis;    echocardiography;    myocardial strain;    speckle tracking;    cardiac magnetic resonance;   

DOI  :  10.3389/fcvm.2021.614235

来源: Frontiers

【 摘 要 】

In the past, the identification of myocardial fibrosis was only possible through invasive histologic assessment. Although endomyocardial biopsy remains the gold standard, recent advances in cardiac imaging techniques have enabled non-invasive tissue characterization of the myocardium, which has also provided valuable insights into specific disease processes. The diagnostic accuracy, incremental yield and prognostic value of speckle tracking echocardiography, late gadolinium enhancement and parametric mapping modules by cardiac magnetic resonance and cardiac computed tomography have been validated against tissue samples and tested in broad patient populations, overall providing relevant clinical information to the cardiologist. This review describes the patterns of left ventricular and left atrial fibrosis, and their characterization by advanced echocardiography, cardiac magnetic resonance and cardiac computed tomography, allowing for clinical applications in sudden cardiac death and management of atrial fibrillation.

【 授权许可】

CC BY