A20/TNFAIP3 Increases ENOS Expression in an ERK5/KLF2-Dependent Manner to Support Endothelial Cell Health in the Face of Inflammation

Frontiers in Cardiovascular Medicine

Franciele C. Kipper¹  Herwig P. Moll²  Lynn Y. Choi²  Cleide Angolano²  Soizic Daniel²  Maria B. Arvelo²  Brian Tung²  Elzbieta Kaczmarek²  Sanah Essayagh²  Gabriel Sauvage²  Andy Lee²  Christiane Ferran³ 

[1] The Division of Neurosurgery and the Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States;The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States;The Division of Vascular and Endovascular Surgery and the Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States;The Transplant Institute and the Division of Nephrology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, United States;

关键词: A20/TNFAIP3;    endothelial nitric oxidase synthase;    inflammation;    Kruppel-like factor 2;    atherosclerosis;    endothelial cell dysfunction;   

DOI  :  10.3389/fcvm.2021.651230

来源: Frontiers

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