CRISPR/Cas System: A Potential Technology for the Prevention and Control of COVID-19 and Emerging Infectious Diseases

Frontiers in Cellular and Infection Microbiology

Haiyan Yang¹  Ronghua Ding¹  Jinzhao Long¹  Yuefei Jin¹  Mingzhu Yuan¹  Shuaiyin Chen¹  Guangcai Duan²  Mengshi Chen³ 

[1] College of Public Health, Zhengzhou University, Zhengzhou, China;College of Public Health, Zhengzhou University, Zhengzhou, China;Key Laboratory of Molecular Medicine in Henan Province, Zhengzhou University, Zhengzhou, China;Hunan Provincial Key Laboratory of Clinical Epidemiology, Xiangya School of Public Health, Central South University, Changsha, China;

关键词: CRISPR/Cas;    SARS-CoV-2;    pathogen detection;    clinical therapy;    drug and vaccine development;   

DOI  :  10.3389/fcimb.2021.639108

来源: Frontiers

【 摘 要 】

The continued global pandemic of coronavirus disease 2019 (COVID-19) poses a serious threat to global public health and social stability and it has become a serious global public health problem. Unfortunately, existing diagnostic and therapeutic approaches for the prevention and control of COVID-19 have many shortcomings. In recent years, the emerging CRISPR/Cas technology can complement the problems of traditional methods. Biological tools based on CRISPR/Cas systems have been widely used in biomedicine. In particular, they are advantageous in pathogen detection, clinical antiviral therapy, drug, and vaccine development. Therefore, CRISPR/Cas technology may have great potential for application in the prevention and control of COVID-19 and emerging infectious diseases in the future. This article summarizes the existing applications of CRISPR/Cas technology in infectious diseases with the aim of providing effective strategies for the prevention and control of COVID-19 and other emerging infectious diseases in the future.

【 授权许可】

CC BY