Susceptibility of ApoB and PCSK9 Genetic Polymorphisms to Diabetic Kidney Disease Among Chinese Diabetic Patients

Frontiers in Medicine

Hailing Zhao¹  Ping Li¹  Yongwei Jiang²  Shaoting Wang²  Yongtong Cao²  Liang Ma²  Meijie Yu³  Wenquan Niu⁴  Xiangling Deng⁴ 

[1] Beijing Key Laboratory of Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China;Clinical Laboratory, China-Japan Friendship Hospital, Beijing, China;Department of Nephrology, China-Japan Friendship Hospital, Beijing, China;Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China;

关键词: diabetic kidney disease;    single nucleotide polymorphism;    association;    ApoB;    risk;   

DOI  :  10.3389/fmed.2021.659188

来源: Frontiers

【 摘 要 】

This study aimed to investigate the susceptibility of 8 polymorphisms in ApoB and PCSK9 genes to diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus. This is a case-control association study, including 575 DKD cases and 653 controls. Genotypes were determined using ligase detection reaction method, and data are analyzed using STATA software. The genotype distributions of rs1042034 and rs12720838 differed significantly between the two groups (P < 0.001 and P = 0.008, respectively). After adjusting for confounding factors, the mutations of rs1042034 and rs12720838 were associated with the significantly increased risk of DKD. For instance, carriers of rs1042034 T allele (CT and TT genotypes) were 1.07 times more likely to have DKD than carriers of rs1042034 CC genotype [odds ratio (OR) = 1.07, 95% confidence interval (CI): 1.03–1.10, P < 0.001]. Further, haplotype T-A-G-T in ApoB gene was overrepresented in cases (18.10%) compared with controls (12.76%) (PSimulated = 0.045), and haplotype T-A-G-T was associated with a 33% increased risk of DKD (OR = 1.33, 95% CI: 1.04, 1.70). In further haplotype-phenotype analysis, significant association was only noted for hypertension and omnibus haplotypes in ApoB gene (PSimulated = 0.001). Our findings indicate that ApoB gene is a candidate gene for DKD in Chinese patients with type 2 diabetes mellitus.

【 授权许可】

CC BY