Heart Transplantation in Mustard Patients Bridged With Continuous Flow Systemic Ventricular Assist Device - A Case Report and Review of Literature

Frontiers in Cardiovascular Medicine

Rody G. Bou Chaaya¹  Jeremy L. Herrmann²  Kashif Saleem²  Mark Turrentine³  Joel W. Simon⁴  Roopa A. Rao⁴  William Aaron Kay⁴  Maya Guglin⁴ 

[1] Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, United States;Division of Cardiothoracic Surgery, Indiana University School of Medicine, Indianapolis, IN, United States;Division of Pediatric Cardiothoracic Surgery, Riley Hospital for Children, Indianapolis, IN, United States;Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, IN, United States;

关键词: ventricular assist device;    mustard procedure;    heart transplantation;    pulmonary hypertension;    d-TGA;    transposition of the great arteries;    pulmonary hypertension reversal;   

DOI  :  10.3389/fcvm.2021.651496

来源: Frontiers

【 摘 要 】

Thirty four-year-old male with history of D-transposition of the great arteries (D-TGA) who underwent Mustard operation at 14 months of age presented in cardiogenic shock secondary to severe systemic right ventricular failure. Catheterization revealed significantly increased pulmonary pressures. Due to the patient's inotrope dependence and prohibitive pulmonary hypertension, he underwent implantation of a Heart Ware HVAD® for systemic RV support. Within 4 months of continuous flow ventricular assist device (VAD) implantation complete normalization of pulmonary vascular resistance (PVR) was achieved. He ultimately underwent orthotopic heart transplantation with favorable outcomes. This is the second report of complete normalization of PVR following VAD implantation into a systemic RV in <4 months. We conducted a thorough literature review to identify Mustard patients that received systemic RV VAD as a bridge to a successful heart transplantation. In this article, we summarize the outcomes and focus on pulmonary hypertension reversibility following VAD implant.

【 授权许可】

CC BY