By Regulating the NLRP3 Inflammasome Can Reduce the Release of Inflammatory Factors in the Co-Culture Model of Tuberculosis H37Ra Strain and Rat Microglia

Frontiers in Cellular and Infection Microbiology

Ye Tian¹  Hao Hui²  Yan Duan³  Gang Zhao³  Qian Yao³  Zhen Xie⁴  Ye Cheng⁴  Meng Zhang⁴  Wu Li⁴ 

[1] Department of Neurology, Department of Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an NO.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, China;Department of Spine Surgery, Honghui Hospital, The Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China;The College of Life Sciences and Medicine, Northwest University, Xi’an, China;The College of Life Sciences and Medicine, Northwest University, Xi’an, China;Department of Neurology, Department of Medical Research Center, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an NO.3 Hospital, The Affiliated Hospital of Northwest University, Xi’an, China;

关键词: CNS tuberculosis infection;    microglia;    NLRP3 inflammasome;    caspase-1;    NF-κB;    P2X7 receptor;   

DOI  :  10.3389/fcimb.2021.637769

来源: Frontiers

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