Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe3O4-GO-ASA Multifunctional Nanobubbles

Frontiers in Medicine

Ming Hu¹  Yang Teng²  Cunyi Chang²  Jinjing Li²  Xiangyu Zhang²  Jie Zhang²  Zheng Liu²  Yanxia Chi³ 

[1] School of Material Science and Engineering, Jiamusi University, Jiamusi, China;School of Pharmacy, Jiamusi University, Jiamusi, China;School of Stomatology, Jiamusi University, Jiamusi, China;

关键词: graphene oxide;    multifunctional nanobubbles;    magnetic target;    thrombosis;    nanobubbles;   

DOI  :  10.3389/fmed.2021.576422

来源: Frontiers

【 摘 要 】

PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe3O4-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distribution range of 200–700 nm. The experimental results showed that PLA-combined Fe3O4-GO-ASA nanobubbles could effectively improve the antithrombin parameters of PT, TT, APTT, and INR, and significantly inhibit thrombosis when the composite nanobubbles with a concentration of 80 mg·mL−1 interacted with the rabbit blood. The prepared composite nanobubbles could reach a significant ultrasonic imaging effect and good magnetic targeting under the magnetic field when the nanobubbles' concentration was only 60 mg·mL−1.

【 授权许可】

CC BY