Long Non-coding RNA: A Key Regulator in the Pathogenesis of Diabetic Cardiomyopathy

Frontiers in Cardiovascular Medicine

Xiaohui Feng¹  Yaoyao Guo¹  Dan Wang¹  Lu Zhang¹  Xiaonan Kang¹  Gang Yuan²  Huihui Ren² 

[1] Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;Branch of National Clinical Research Center for Metabolic Disease, Wuhan, China;

关键词: diabetes mellilus;    diabetic cardiomyopathy;    long non-coding RNA;    hypertrophy;    fibrosis;   

DOI  :  10.3389/fcvm.2021.655598

来源: Frontiers

【 摘 要 】

In recent years, diabetes mellitus has become a global issue with increasing incidence rate worldwide. Diabetic cardiomyopathy (DCM), one of the important complications of diabetes, refers to patients with type 1 and type 2 diabetes who have ventricular hypertrophy, fibrosis and even diastolic dysfunction. The pathogenesis of DCM is related to oxidative stress, inflammatory response, apoptosis, autophagy, myocardial fibrosis and, diabetic microangiopathy. Long non-coding RNAs (lncRNA) is a non-coding RNA with a length longer than 200 nucleotides which lack the ability of protein coding. With the development of molecular technology, massive evidence demonstrates that lncRNA play a critical role in the molecular mechanism of DCM. Moreover, it can also be used as potential diagnostic markers for DCM. In this review, we intend to summarize the pathological roles and molecular mechanism of lncRNA in the progression of diabetic cardiomyopathy, which may provide promising diagnosis and treatment strategies for DCM.

【 授权许可】

CC BY