Clonal Evolution Dynamics in Primary and Metastatic Lesions of Pancreatic Neuroendocrine Neoplasms

Frontiers in Medicine

Yi Zheng¹  Zhou Tong¹  Lulu Liu¹  Peng Zhao¹  Hangyu Zhang¹  Weijia Fang²  Weiliang Xia³  Yanwu Zeng⁴  Weiwei Shi⁴  Chunlei Chen⁵  Lin Wang⁶ 

[1] Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;OrigiMed, Shanghai, China;State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;

关键词: clonal evolution;    pancreatic neuroendocrine neoplasms;    heterogeneity;    liver metastasis;    next-generation sequencing;   

DOI  :  10.3389/fmed.2021.620988

来源: Frontiers

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