Brief Overview of Approaches and Challenges in New Antibiotic Development: A Focus On Drug Repurposing

Frontiers in Cellular and Infection Microbiology

Natalie K. Boyd¹  Christopher R. Frei²  Chengwen Teng³ 

[1] College of Pharmacy, The University of Texas at Austin, San Antonio, TX, United States;Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States;College of Pharmacy, The University of Texas at Austin, San Antonio, TX, United States;Long School of Medicine, University of Texas Health San Antonio, San Antonio, TX, United States;Research Department, South Texas Veterans Health Care System, San Antonio, TX, United States;Pharmacy Department, University Health System, San Antonio, TX, United States;Department of Clinical Pharmacy and Outcomes Sciences, College of Pharmacy, The University of South Carolina, Columbia, SC, United States;

关键词: drug repurposing;    antibiotics;    drug development;    translational science;    reverse translation;   

DOI  :  10.3389/fcimb.2021.684515

来源: Frontiers

【 摘 要 】

Drug repurposing, or identifying new uses for existing drugs, has emerged as an alternative to traditional drug discovery processes involving de novo synthesis. Drugs that are currently approved or under development for non-antibiotic indications may possess antibiotic properties, and therefore may have repurposing potential, either alone or in combination with an antibiotic. They might also serve as “antibiotic adjuvants” to enhance the activity of certain antibiotics.

【 授权许可】

CC BY