Thrombolytic Therapy During ex-vivo Normothermic Machine Perfusion of Human Livers Reduces Peribiliary Vascular Plexus Injury

Frontiers in Surgery

Sofia Baptista¹  Ivy Rosales²  Heidi Yeh²  James F. Markmann²  Cailah Carroll³  Taylor M. Coe⁴  Siavash Raigani⁴  Korkut Uygun⁴  Omar Haque⁵  Francis L. Delmonico⁶ 

[1] Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, United States;Shriners Hospitals for Children, Boston, MA, United States;Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States;Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, United States;Harvard Medical School, Boston, MA, United States;Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States;Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, United States;Shriners Hospitals for Children, Boston, MA, United States;Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States;Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, United States;Shriners Hospitals for Children, Boston, MA, United States;Harvard Medical School, Boston, MA, United States;Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States;Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA, United States;Center for Engineering in Medicine and Surgery, Massachusetts General Hospital, Boston, MA, United States;Shriners Hospitals for Children, Boston, MA, United States;Harvard Medical School, Boston, MA, United States;Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, United States;Harvard Medical School, Boston, MA, United States;New England Donor Services (NEDS), Waltham, MA, United States;

关键词: liver transplant;    tissue plasminogen activator;    normothermic machine liver perfusion;    peribiliary vascular plexus;    biliary injury;    split liver technique;    mural stroma;    donation after circulatory death;   

DOI  :  10.3389/fsurg.2021.644859

来源: Frontiers

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