The Role of Non-coding RNAs in Diabetic Nephropathy-Related Oxidative Stress

Frontiers in Medicine

Yi Zuo¹  Suxian Zhou¹  Gaoyan Kuang²  Xiaoyun He³  Chunlin Ou⁴  Shuangxi Li⁵ 

[1] Department of Endocrinology, Affiliated Hospital of Guilin Medical University, Guilin, China;Department of Orthopedics, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China;Department of Pathology, Xiangya Hospital, Central South University, Changsha, China;Department of Pathology, Xiangya Hospital, Central South University, Changsha, China;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China;Department of Pathophysiology, Hunan University of Medicine, Huaihua, China;

关键词: diabetic nephropathy;    oxidative stress;    ncRNA;    mircoRNA;    therapeutic target;   

DOI  :  10.3389/fmed.2021.626423

来源: Frontiers

【 摘 要 】

Diabetic nephropathy (DN) is one of the main complications of diabetes and the main cause of diabetic end-stage renal disease, which is often fatal. DN is usually characterized by progressive renal interstitial fibrosis, which is closely related to the excessive accumulation of extracellular matrix and oxidative stress. Non-coding RNAs (ncRNAs) are RNA molecules expressed in eukaryotic cells that are not translated into proteins. They are widely involved in the regulation of biological processes, such as, chromatin remodeling, transcription, post-transcriptional modification, and signal transduction. Recent studies have shown that ncRNAs play an important role in the occurrence and development of DN and participate in the regulation of oxidative stress in DN. This review clarifies the functions and mechanisms of ncRNAs in DN-related oxidative stress, providing valuable insights into the prevention, early diagnosis, and molecular therapeutic targets of DN.

【 授权许可】

CC BY