Rodent Models for the Study of Soil-Transmitted Helminths: A Proteomics Approach

Frontiers in Cellular and Infection Microbiology

Javier Sotillo¹  Karen J. Montaño¹  Carmen Cuéllar² 

[1] Centro Nacional de Microbiología, Instituto de Salud Carlos III, Madrid, Spain;Departamento de Microbiología y Parasitología, Facultad de Farmacia, Universidad Complutense, Madrid, Spain;

关键词: proteomics;    soil-transmitted helminths (STHs);    host-parasite interactions;    Nippostrongylus brasiliensis;    Heligmosomoides polygyrus;    Trichuris muris;    vaccines;    immunomodulation;   

DOI  :  10.3389/fcimb.2021.639573

来源: Frontiers

【 摘 要 】

Soil-transmitted helminths (STH) affect hundreds of millions worldwide and are some of the most important neglected tropical diseases in terms of morbidity. Due to the difficulty in studying STH human infections, rodent models have become increasingly used, mainly because of their similarities in life cycle. Ascaris suum and Trichuris muris have been proven appropriate and low maintenance models for the study of ascariasis and trichuriasis. In the case of hookworms, despite most of the murine models do not fully reproduce the life cycle of Necator americanus, their proteomic similarity makes them highly suitable for the development of novel vaccine candidates and for the study of hookworm biological features. Furthermore, these models have been helpful in elucidating some basic aspects of our immune system, and are currently being used by numerous researchers to develop novel molecules with immunomodulatory proteins. Herein we review the similarities in the proteomic composition between Nippostrongylus brasiliensis, Heligmosomoides polygyrus bakeri and Trichuris muris and their respective human counterpart with a focus on the vaccine candidates and immunomodulatory proteins being currently studied.

【 授权许可】

CC BY