Metformin, the Rise of a New Medical Therapy for Endometriosis? A Systematic Review of the Literature

Frontiers in Medicine

Tessa E. R. Gillon¹  Emanuela Stochino-Loi¹  Anis Feki¹  Jean Bouquet de Joliniere¹  Attila L. Major²  Jean-Marc Ayoubi³ 

[1] Department of Obstetrics and Gynecology, Cantonal Hospital, University of Fribourg, Fribourg, Switzerland;Department of Obstetrics and Gynecology, Cantonal Hospital, University of Fribourg, Fribourg, Switzerland;Femina Gynecology Center, Geneva, Switzerland;Department of Obstetrics and Gynecology, Foch Hospital, University of West Paris, Suresnes, France;

关键词: endometriosis;    medical therapy;    metformin;    contraceptives;    fertility;   

DOI  :  10.3389/fmed.2021.581311

来源: Frontiers

【 摘 要 】

Medical treatments for endometriosis aim to control pain symptoms and stop progression of endometriotic lesions. However, their adverse effects and their contraceptive effect in women who desire pregnancy, limit their long terms use. Although there is only one study investigating the effects of metformin on women with endometriosis, metformin seems to have a unique therapeutic potential. It may be a helpful anti-inflammatory and antiproliferative agent in the treatment of endometriosis. As such metformin may be more beneficial thanks to the lack of serious side effects.

【 授权许可】

CC BY