Amylases: Biofilm Inducer or Biofilm Inhibitor?

Frontiers in Cellular and Infection Microbiology

Siddhartha Pati¹  Sushil Kumar Pathak²  Rina Rani Ray³  Ankita Dey³  Moupriya Nag⁴  Dibyajit Lahiri⁴  Dipro Mukherjee⁴  Sayantani Garai⁴  Ritwik Banerjee⁴  Tanmay Sarkar⁵  Hassan I. Sheikh⁶  Hisham Atan Edinur⁷ 

[1] Centre of Excellence, Khallikote University, Berhampur, India;Research Division, Association for Biodiversity Conservation and Research (ABC), Balasore, India;Department of Bioscience and Bioinformatics, Khallikote University, Berhampur, India;Department of Biotechnology, Maulana Abul Kalam Azad University of Technology, Haringhata, India;Department of Biotechnology, University of Engineering & Management, Kolkata, India;Department of Food Technology and Bio-Chemical Engineering, Jadavpur University, Kolkata, India;Malda Polytechnic, West Bengal State Council of Technical Education, Government of West Bengal, Malda, India;Faculty of Fisheries and Food Science, Universiti Malaysia Terengganu, Kuala Nerus, Malaysia;School of Health Sciences, Universiti Sains Malaysia, Penang, Malaysia;

关键词: biofilm;    sessile;    antibiofilm;    amylase;    antimicrobial;   

DOI  :  10.3389/fcimb.2021.660048

来源: Frontiers

【 摘 要 】

Biofilm is a syntrophic association of sessile groups of microbial cells that adhere to biotic and abiotic surfaces with the help of pili and extracellular polymeric substances (EPS). EPSs also prevent penetration of antimicrobials/antibiotics into the sessile groups of cells. Hence, methods and agents to avoid or remove biofilms are urgently needed. Enzymes play important roles in the removal of biofilm in natural environments and may be promising agents for this purpose. As the major component of the EPS is polysaccharide, amylase has inhibited EPS by preventing the adherence of the microbial cells, thus making amylase a suitable antimicrobial agent. On the other hand, salivary amylase binds to amylase-binding protein of plaque-forming Streptococci and initiates the formation of biofilm. This review investigates the contradictory actions and microbe-associated genes of amylases, with emphasis on their structural and functional characteristics.

【 授权许可】

CC BY