Reprogramming Intestinal Epithelial Cell Polarity by Interleukin-22

Frontiers in Medicine

Robert Sabat¹  Kerstin Wolk¹  Lydia Lebenheim²  Deborah Delbue²  Michael Schumann²  Subhakankha Manna²  Britta Siegmund²  Claudia Heldt²  Danielle Cardoso-Silva²  Violaine Dony²  Markus M. Heimesaat³  Melba Muñoz⁴  Jan F. Richter⁵  Susanne M. Krug⁶ 

[1] Department for Dermatology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany;Department of Dermatology, Venereology and Allergology, Psoriasis Research and Treatment Center, Institute of Medical Immunology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany;Department for Gastroenterology, Rheumatology and Infectious Diseases, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany;Department of Microbiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany;Department of Microbiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany;Department for Dermatology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany;Institute for Anatomy II, University of Jena, Jena, Germany;Institute of Clinical Physiology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany;

关键词: intestinal epithelial cells;    barrier function;    cell polarity;    IL-22;    tight junctions;    MAPK;    stat3;   

DOI  :  10.3389/fmed.2021.656047

来源: Frontiers

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