One-Year Update on Salivary Diagnostic of COVID-19

Frontiers in Public Health

Lina Maria Marin¹  Walter Luiz Siqueira¹  Robinson Sabino-Silva²  Douglas Carvalho Caixeta²  Leia Cardoso-Sousa²  Stephanie Wutke Oliveira³  Mario Machado Martins⁴  Luiz Ricardo Goulart⁴  Ana Carolina Gomes Jardim⁵  Thulio Marquez Cunha⁶ 

[1] College of Dentistry, University of Saskatchewan, Saskatoon, SK, Canada;Innovation Center in Salivary Diagnostic and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil;Innovation Center in Salivary Diagnostic and Nanotheranostics, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Brazil;School of Dentistry, Federal University of Uberlandia, Uberlandia, Brazil;Institute of Genetics and Biochemistry, Federal University of Uberlandia, Uberlandia, Brazil;Laboratory of Virology, Institute of Biomedical Science, Federal University of Uberlandia, Uberlandia, Brazil;São Paulo State University, Institute of Biosciences, Humanities and Exact Sciences, São José Do Rio Preto, Brazil;School of Medicine, Federal University of Uberlandia, Uberlandia, Brazil;

关键词: nasopharyngeal swabs;    saliva;    diagnostic test;    salivary diagnostic;    SARS-CoV-2;    COVID-19;   

DOI  :  10.3389/fpubh.2021.589564

来源: Frontiers

【 摘 要 】

Background: Coronavirus disease 2019 (COVID-19) is a global health problem, which is challenging healthcare worldwide. In this critical review, we discussed the advantages and limitations in the implementation of salivary diagnostic platforms of COVID-19. The diagnostic test of COVID-19 by invasive nasopharyngeal collection is uncomfortable for patients and requires specialized training of healthcare professionals in order to obtain an appropriate collection of samples. Additionally, these professionals are in close contact with infected patients or suspected cases of COVID-19, leading to an increased contamination risk for frontline healthcare workers. Although there is a colossal demand for novel diagnostic platforms with non-invasive and self-collection samples of COVID-19, the implementation of the salivary platforms has not been implemented for extensive scale testing. Up to date, several cross-section and clinical trial studies published in the last 12 months support the potential of detecting SARS-CoV-2 RNA in saliva as a biomarker for COVID-19, providing a self-collection, non-invasive, safe, and comfortable procedure. Therefore, the salivary diagnosis is suitable to protect healthcare professionals and other frontline workers and may encourage patients to get tested due to its advantages over the current invasive methods. The detection of SARS-CoV-2 in saliva was substantial also in patients with a negative nasopharyngeal swab, indicating the presence of false negative results. Furthermore, we expect that salivary diagnostic devices for COVID-19 will continue to be used with austerity without excluding traditional gold standard specimens to detect SARS-CoV-2.

【 授权许可】

CC BY