Urinary Microbiome: Yin and Yang of the Urinary Tract

Frontiers in Cellular and Infection Microbiology

Miguel Soriano¹  Ana Soriano-Lerma²  Virginia Perez-Carrasco³  Jose A. Garcia-Salcedo³  José Gutiérrez-Fernández⁴ 

[1] GENYO, Centre for Genomics and Oncological Research, Pfizer, University of Granada, Granada, Spain;Center for Intensive Mediterranean Agrosystems and Agri-food Biotechnology (CIAMBITAL), University of Almeria, Almeria, Spain;GENYO, Centre for Genomics and Oncological Research, Pfizer, University of Granada, Granada, Spain;Department of Physiology, Faculty of Pharmacy, Institute of Nutrition and Food Technology “Jose’ Mataix”, University of Granada, Granada, Spain;GENYO, Centre for Genomics and Oncological Research, Pfizer, University of Granada, Granada, Spain;Microbiology Unit, University Hospital Virgen de las Nieves, Biosanitary Research Institute (IBS.Granada), Granada, Spain;Microbiology Unit, University Hospital Virgen de las Nieves, Biosanitary Research Institute (IBS.Granada), Granada, Spain;

关键词: microbiome;    urinary tract;    infection;    disease;    health;    sequencing;   

DOI  :  10.3389/fcimb.2021.617002

来源: Frontiers

【 摘 要 】

The application of next generation sequencing techniques has allowed the characterization of the urinary tract microbiome and has led to the rejection of the pre-established concept of sterility in the urinary bladder. Not only have microbial communities in the urinary tract been implicated in the maintenance of health but alterations in their composition have also been associated with different urinary pathologies, such as urinary tract infections (UTI). Therefore, the study of the urinary microbiome in healthy individuals, as well as its involvement in disease through the proliferation of opportunistic pathogens, could open a potential field of study, leading to new insights into prevention, diagnosis and treatment strategies for urinary pathologies. In this review we present an overview of the current state of knowledge about the urinary microbiome in health and disease, as well as its involvement in the development of new therapeutic strategies.

【 授权许可】

CC BY