Synovial Fibrosis Involvement in Osteoarthritis

Frontiers in Medicine

Mingchao Li¹  Xiaochen Li¹  Runlin Xing²  Jun Mao²  Zhengquan Huang²  Liang Ding²  Peimin Wang²  Li Zhang² 

[1] Departments of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Departments of Orthopedics, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China;Jiangsu Province Hospital of Chinese Medicine, Nanjing, China;

关键词: osteoarthritis;    fibrosis;    synovitis;    fibroblast-like synoviocytes;    extracellular matrix;   

DOI  :  10.3389/fmed.2021.684389

来源: Frontiers

【 摘 要 】

Bone changes have always been the focus of research on osteoarthritis, but the number of studies on synovitis has increased only over the last 10 years. Our current understanding is that the mechanism of osteoarthritis involves all the tissues that make up the joints, including nerve sprouting, pannus formation, and extracellular matrix environmental changes in the synovium. These factors together determine synovial fibrosis and may be closely associated with the clinical symptoms of pain, hyperalgesia, and stiffness in osteoarthritis. In this review, we summarize the consensus of clinical work, the potential pathological mechanisms, the possible therapeutic targets, and the available therapeutic strategies for synovial fibrosis in osteoarthritis to gain insight and provide a foundation for further study.

【 授权许可】

CC BY