Novel Urinary Glycan Biomarkers Predict Cardiovascular Events in Patients With Type 2 Diabetes: A Multicenter Prospective Study With 5-Year Follow Up (U-CARE Study 2)

Frontiers in Cardiovascular Medicine

Kenichi Shikata¹  Satoshi Miyamoto¹  Michihiro Yoshida¹  Haruhito A. Uchida²  Kazuyuki Hida³  Jun Wada⁴  Mariko Imamura⁴  Mayu Watanabe⁴  Jun Eguchi⁴  Koki Mise⁴  Atsuko Nakatsuka⁴  Chigusa Higuchi⁴  Satoshi Yamaguchi⁴  Akihiro Katayama⁵  Masao Yamada⁶  Katsuhiro Miyashita⁷  Takashi Matsuoka⁸  Kazutoshi Murakami⁸  Shinji Kamei⁸  Tomokazu Nunoue⁹  Shinichiro Ando^1,10  Sanae Teshigawara^1,11  Atsuhito Tone^1,11  Tatsuaki Nakato^1,11  Ikki Shimizu^1,12 

[1] Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama, Japan;Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Department of Diabetology and Metabolism, National Hospital Organization Okayama Medical Center, Okayama, Japan;Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan;Diabetes Center, Okayama University Hospital, Okayama, Japan;GlycoTechnica Ltd., Yokohama, Japan;Japanese Red Cross Okayama Hospital, Okayama, Japan;Kurashiki Central Hospital, Kurashiki, Japan;Nunoue Clinic, Tsuyama, Japan;Okayama City General Medical Center, Okayama, Japan;Okayama Saiseikai General Hospital, Okayama, Japan;The Sakakibara Heart Institute of Okayama, Okayama, Japan;

关键词: cardiovascular event;    diabetes;    lectins;    N-glycans;    urinary biomarkers;   

DOI  :  10.3389/fcvm.2021.668059

来源: Frontiers

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