Plasma Protein Layer Concealment Protects Streptococcus pyogenes From Innate Immune Attack

Frontiers in Cellular and Infection Microbiology

Hilger Jagau¹  Heiko Herwald¹  Swathi Packirisamy¹  Kyle Brandon² 

[1] Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden;Division of Infection Medicine, Department of Clinical Sciences, Lund, Lund University, Lund, Sweden;UCD School of Medicine, University College Dublin, Dublin, Ireland;

关键词: antibiotic resistance;    antimicrobials;    cold atmospheric plasma (CAP);    hemostasis;    innate immune system;    Streptococcus pyogenes;   

DOI  :  10.3389/fcimb.2021.633394

来源: Frontiers

【 摘 要 】

Early recognition and elimination of invading pathogens by the innate immune system, is one of the most efficient host defense mechanisms preventing the induction of systemic complications from infection. To this end the host can mobilize endogenous antimicrobials capable of killing the intruder by perforating the microbial cell wall. Here, we show that Streptococcus pyogenes can shield its outer surface with a layer of plasma proteins. This mechanism protects the bacteria from an otherwise lytic attack by LL-37 and extracellular histones, allowing the bacteria to adjust their gene regulation to an otherwise hostile environment.

【 授权许可】

CC BY