Ginsenoside Rb1 Enhances Plaque Stability and Inhibits Adventitial Vasa Vasorum via the Modulation of miR-33 and PEDF

Frontiers in Cardiovascular Medicine

Rui Li¹  Hongyan Dai²  Rong Guo³  Huili Lin³  Lei Wang⁴  Mei Ni⁴  Zihao Zhang⁴  Xiaorong Luan⁴  Mei Dong⁴  Huixia Lu⁴  Jiayi Hu⁴  Lei Zhang⁴  Xiaoling Liu⁴  Xiaoyan Yang⁵  Xue Zhang⁶  Minghao Liu⁷  Hao Wen⁸ 

[1] Department of Cardiology, China-Japan Friendship Hospital, Ministry of Health, Beijing, China;Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China;Department of Cardiology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;Department of Cardiology, Heart Center and Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;Department of Cardiology, Qingdao Municipal Hospital, Qingdao, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China;The Second School of Clinical Medicine, Binzhou Medical University, Yantai, China;

关键词: ginsenoside Rb;    atherosclerosis;    plaque stability;    vasa vasorum;    PEDF;   

DOI  :  10.3389/fcvm.2021.654670

来源: Frontiers

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