Therapeutic Exosomes in Prognosis and Developments of Coronary Artery Disease

Frontiers in Cardiovascular Medicine

Yue Gu¹  Ai-Qun Chen¹  Zhi-Mei Wang¹  Feng Wang¹  Shuai Luo¹  Shao-Liang Chen²  Xiao-Fei Gao²  Jun-Jie Zhang² 

[1] Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, Nanjing, China;Department of Cardiology, Nanjing Heart Centre, Nanjing, China;

关键词: exosomes;    CAD;    atherosclerosis;    myocardial infarction;    drug delivery;   

DOI  :  10.3389/fcvm.2021.691548

来源: Frontiers

【 摘 要 】

Exosomes, with an diameter of 30~150 nm, could be released from almost all types of cells, which contain diverse effective constituent, such as RNAs, proteins, lipids, and so on. In recent years, exosomes have been verified to play an important role in mechanism, diagnosis, treatment, and prognosis of cardiovascular disease, especially coronary artery disease (CAD). Moreover, it has also been shown that exosomes derived from different cell types have various biological functions based on the cell stimulation and microenvironment. However, therapeutic exosomes are currently far away from clinical translation, despite it is full of hope. In this review, we summarize an update of the recent studies and systematic knowledge of therapeutic exosomes in atherosclerosis, myocardial infarction, and in-stent restenosis, which might provide a novel insight into the treatment of CAD and promote the potential clinical application of therapeutic exosomes.

【 授权许可】

CC BY