Dynamic behaviour of atomic force microscope-based nanomachining based on a modified couple stress theory

Micro & nano letters

article

Win-Jin Chang¹  Yu-Ching Yang¹  Haw-Long Lee¹ 

[1] Department of Mechanical Engineering, Kun Shan University

关键词: atomic force microscopy;    cantilevers;    cutting;    machining;    vibrations;    dynamic behaviour;    atomic force microscope;    nanomachining;    modified couple stress theory;    dynamic displacement;    AFM cantilever;    size-dependence;    vibration behaviour;    classical beam theory;    cutting depth;    excitation frequency;    natural frequency;    material removal rate;   

DOI  :  10.1049/mnl.2013.0493

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background: The outbreak caused by SARS CoV-2 of the recent coronavirus disease-2019 (COVID-19) has been marked as a public health concern with a significant mortality at the global level. Lignocaine a common anesthetic agent being used for pain free surgeries for over a long period of time has expressed extensive characteristic of being an anti-inflammatory, antibacterial, direct spasmolytic,  ion channel blocking and repolarization agent. We did a literature review Methodology: Currently compiled over-view has for the first time evaluated the probable curative and therapeutic role of nebulized lignocaine drug against SARS CoV-2 by utilization of PubMed, MEDLINE, NHS Evidence and Web of Science databases. Results: With evidence of nebulized lignocaine being used successfully in respiratory illness before and the established role of low concentration lignocaine as ion channel repolarization agent, we try to interpret and deduce the possible implication of nebulized lignocaine as possible therapeutic agent and a potential cure against SARS-CoV-2 caused respiratory illness by acting as an anti-inflammatory agent during SARS-CoV-2 caused acute lung injury and also possibly as an antiviral drug.  Conclusion: By the virtue of possessing anti-inflammatory effect and potential antiviral effects, nebulized lignocaine can be a breakthrough in the management of the current COVID-19 pandemic.

【 授权许可】

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