Graphene-based THz modulator analysed by equivalent circuit model

Micro & nano letters

article

Binggang Xiao¹  Jing Chen¹  Zhiyi Xie¹  Sanshui Xiao² 

[1] College of Information Engineering, Ji Liang University of China;Department of Photonics Engineering, Technical University of Denmark

关键词: terahertz wave devices;    equivalent circuits;    modulators;    graphene;    graphene based THz modulator;    equivalent circuit model;    equivalent transmission line;    graphene conductivity;    Fresnel transfer matrices;    bandwidth 55.5 kHz;    C;   

DOI  :  10.1049/mnl.2016.0107

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Objective: Alpha-2 adrenoceptors have recently been used perioperatively for their sedative, analgesic,sympatholytic and cardiovascular stabilizing effects. The efficacy of clonidine as an adjuvant in providingmonitored anesthesia care (MAC) for ear, nose and throat (ENT) surgeries has not been much investigated,so we conducted this study.Methodology: In this prospective double blind randomized placebo controlled study, 90 patients postedfor elective ENT surgeries under local anesthesia with MAC were included and divided into 3 groups of 30each. In Group CBI patients received clonidine 3 μg/kg intravenous bolus followed by clonidine infusionat 0.3 μg/kg/hr. Patients of Group CB received clonidine 3 μg/kg bolus followed by placebo infusion andin Group P patients received placebo bolus followed by placebo infusion. All three Groups receivedsimilar premedication of intravenous midazolam 0.03 mg/kg and fentanyl 2 μg/kg. Demographic data,intraoperative vital parameters, observer’s assessment and alertness scale (OAAS) score for sedation,bleeding score, patient and surgeon satisfaction score, postoperative Aldrete score, visual analogue scale(VAS) score for analgesia, rescue sedative and analgesic consumption and complications were noted.Results: OAAS score (0-noresponse to 5-awake), 10 min after infusion of study drug was significantlylower in Groups CBI (2.06 ± 0.61) and CB (2.83 ± 0.70) signifying superior sedation as compared toplacebo Group (4.80 ± 0.40), (p=0.000). Intraoperative rescue sedative and analgesic consumption weresignificantly lower in Groups CBI and CB, as compared to placebo group (p = 0.000). Mean heart rate (HR)and mean arterial pressure (MAP) were significantly lower in Groups CBI and CB as compared to GroupP (p = 0.000). Intraoperative bleeding score (0-Nolbleeding to 4-modearte bleeding) was significantlylower in Group CBI (0.86 ± 0.68) and CB (1.36 ± 0.76) as compared to placebo (3.10 ± 0.54), p = 0.000.Surgeons and patients were more satisfied in clonidine Groups CBI and CB, (p = 0.000). Patients of GroupCBI demonstrated better sedation profile, less bleeding score and higher satisfaction scores as comparedto Group CB (p<0.05).Conclusion: Being a safe, well tolerated, cheap and effective regime, our study favors the use of clonidine3 μg/kg IV bolus followed by infusion of 0.3 μg/kg/hr as an adjunct to conventional MAC regime ofmidazolam and fentanyl in ENT surgeries as it provides effective sedation and bloodless surgical field.

【 授权许可】

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