Simple method for fabricating highly electrically conductive PU composite with carbon@polyaniline@silver core-double-shell microspheres

Micro & nano letters

article

Yuan Yin¹  Bin Zhang¹  Jian Han¹ 

[1] Zhejiang Provincial Key Laboratory of Industrial Textile Materials & Manufacturing Technology, College of Materials and Textiles, Zhejiang Sci-Tech University

关键词: filled polymers;    carbon;    silver;    conducting polymers;    electrical conductivity;    electrical resistivity;    materials preparation;    electrical conductivity;    polyurethane-carbon-polyaniline-silver core-double-shell microsphere composite;    electrical resistivity;    surface resistivity;    structure stability;    PANI;    C;    Ag;   

DOI  :  10.1049/mnl.2017.0329

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background:  Hearing loss is a major side effect of cisplatin-based chemotherapy. With a large burden of cancer in developing countries, an evidence-based approach to prevention of cisplatin-induced hearing loss (ototoxicity) is pertinent. Aim:  This study aimed to evaluate the efficacy of treatment modifications currently being implemented to prevent or minimise ototoxicity during cisplatin-based chemotherapy. Setting:  A retrospective medical folder review design was employed. Purposive sampling was used to select medical folders of adult patients who were undergoing cisplatin-based chemotherapy at Groote Schuur Hospital between January 2011 and December 2016. Method:  Demographic, cisplatin chemotherapy treatment and audiometric data were extracted from patients’ records. The Common Terminology Criteria of Adverse Events version 4 (CTCAE v4) grading scale was used to determine ototoxicity and grade severity of hearing loss. Data were analysed using R, a software environment for statistical computing. Results:  Fifty-eight medical folders were included in the study (median age = 43 years; range: 18–75 years; 36 male, 22 female; average length of treatment: 13.45 weeks). Three treatment modifications were used: Dose reduction, switching drugs and continuing with the same drug. Common Terminology Criteria of Adverse Events version 4 grading scale revealed ototoxicity in 75 % of the patients who switched drugs, 50% of the patients with reduced dose and 56 % of the patients who were continued on the same drug. There was no statistically significant association between treatment modifications and incidence of ototoxicity. Conclusion:  Most patients experienced cisplatin-induced ototoxicity despite treatment modifications. There was no statistically significant association between any of the strategies implemented and incidence of hearing loss.

【 授权许可】

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