Electrophoretic kinetics of nanomullite, nanoSiC and their composite suspensions

Micro & nano letters

article

Mohammad Sadegh Shakeri¹  Masoud Alizadeh¹  Asghar Kazemzadeh¹  Touradj Ebadzadeh¹  Hossein Aghajani² 

[1] Materials and Energy Research Center (MERC);Department of Materials Engineering, University of Tabriz

关键词: alumina;    silicon compounds;    nanocomposites;    electrophoresis;    suspensions;    ionisation;    nanoparticles;    pH;    surface charging;    particle size;    current density;    surfactants;    electrical conductivity;    electrical resistivity;    permittivity;    electrophoretic kinetics;    nanomullite;    composite suspensions;    nanosilicon carbide;    particle ionisation;    pH;    surface charge;    particle size distribution;    zeta potential;    current density;    electrophoresis movement;    time-weight curves;    powders;    polyvinyl pyrrolidone;    applied electrical field;    surfactant;    free ion concentration;    particle conductivity;    electric resistance;    permittivity;    Al2O3-SiO2-SiC;   

DOI  :  10.1049/mnl.2017.0290

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Background: Steroids have been reported to possess analgesic and anti-inflammatory activities, and Vernonia glaberrima also possesses analgesic and anti-inflammatory properties. Aim: The aim of the study was to evaluate the effect of lupeol isolated from the n-hexane soluble fraction of the methanol leaf extract of V. glaberrima on pain and inflammation. Method: Lupeol was re-isolated from the leaf of V. glaberrima by using chromatographic procedures; it was subjected to analgesic and anti-inflammatory studies by using acetic acid-induced writhing test in mice and formalin-induced pain and inflammation in rats, respectively. The intraperitoneal lethal dose (LD 50 ) of lupeol was determined by using Lorke’s method. Results: The results of the study showed that lupeol significantly ( p < 0.05) decreased writhing response at doses 12.5 mg/kg, 25.0 mg/kg and 50.0 mg/kg corresponding to percentage inhibition of 83.60%, 83.63% and 80.02%, respectively. This was higher than piroxicam, the standard drug (73.8%), at 10 mg/kg. The compound was also able to significantly ( p < 0.05) reduce nociceptive response in both phases of the formalin test, and there was a remarkable reduction of oedema by the compound at the second, third and fourth hours. The median LD 50 of the compound was estimated to be greater than 5000 mg/kg. Conclusion: The findings of this study indicated that lupeol from the leaf of V. glaberrima has good analgesic and anti-inflammatory activity that validates the ethnomedicinal use of the plant in the treatment of pain and inflammatory conditions.

【 授权许可】

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