Preparation and characterisation of ginkgolide nanoparticles via the emulsion solvent evaporation method

Micro & nano letters

article

Jianfang Jiang¹  Juan Ao¹  Chunyang He¹  Jun Xiong¹  Jiaqi Zhao¹  Jintao Liu¹  Shengrong You¹  Hao Jiang² 

[1] School of Pharmacy, Zunyi Medical College;Institute of Agricultural Resources and Regional Planning, Chinese Academy of Agricultural Sciences

关键词: nanoparticles;    particle size;    nanofabrication;    organic compounds;    nanomedicine;    vacuum deposition;    drugs;    electrokinetic effects;    surface morphology;    ginkgolide nanoparticles;    emulsion solvent evaporation method;    cardiovascular disease treatment;    cerebrovascular disease treatment;    hydrodynamic diameter;    surface zeta potential;    surface morphology;    nanomaterials;    particle size;    pharmacokinetics;   

DOI  :  10.1049/mnl.2017.0906

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Acute rheumatic fever (ARF) is an inflammatory collagenous tissue disease which shows its cardinal signs in joints, heart, skin and nervous system while affecting whole connective tissue system more or less. This study was conducted in order to investigate the clinical pattern and severity of ARF, echocardiographic findings and the course of the patients with heart valve involvement by studying the clinical and laboratory aspects of the patients diagnosed with ARF according to updated Jones criteria. The study included 214 patients diagnosed with ARF for the first time between January 2005 and May 2008. All patients were scanned with doppler echocardiography (ECHO) between certain intervals. Severity of carditis was grouped into 3 groups of mild, moderate and severe. The frequency of carditis was 57.9%, arthritis was 73.4%, chorea was 11.7% and erythema marginatum was 0.9% but no subcutaneous nodules. Recovery was observed in 22% of the cases of isolated aortic insufficiency (AI), 50% of the cases with isolated mitral insufficiency (MI) and 80% of the cases with mitral and aortic insufficiencies together (MI+AI). Recovery in isolated MI was significantly much more than recovery in isolated AI. However, recovery in AI was significantly much more than in MI in cases of mitral and aortic insufficiencies together. In conclusion, ARF is a cause of acquired and preventable heart disease and it can be reversed through right diagnosis and appropriate treatment. Isolated mitral insufficiency, isolated aortic insufficiency and both mitral and aortic insufficiency are observed during a valvular disease. Remission among valvular diseases are most commonly in those with mitral insufficiency and remissions in both mitral and aortic insufficiency occur most commonly in aortic ones. Regular prophylaxis is the key element for long term prevention of patients with ARF .

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND