Pulmonary toxicity of exposure to nano nickel oxide

Micro & nano letters

article

Xuhong Chang¹  Hongjun Zhao²  Jinxia Gao³  Lijuan Chen²  An Zhu¹  Cheng Wang¹  Shu Yu¹  Xiaolan Ren²  Pengfei Ge²  Yingbiao Sun¹ 

[1] Department of Toxicology, School of Public Health, Lanzhou University;Department of Chronic Noncommunicable Disease Control and Prevention, Gansu Provincial Centre for Disease Control and Prevention;Lanzhou Municipal Center for Disease Control

关键词: pneumodynamics;    toxicology;    nickel compounds;    nanostructured materials;    size effect;    cellular biophysics;    enzymes;    molecular biophysics;    pulmonary toxicity;    nanonickel oxide exposure;    combined toxicity effects;    meta-analysis;    cell data;    rat models;    standardised mean difference;    computational equations;    size effect;    in vitro experiments;    lactate dehydrogenase;    cell viability;    bronchoalveolar lavage fluid;    neutrophils;    alveolar macrophage;    chemokines;    pro-inflammation cytokines;    human respiratory system;    time 1 week to 3 month;    NiO;   

DOI  :  10.1049/mnl.2017.0802

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The Coronavirus Disease (COVID-19) has recently emerged as a human pathogen caused by SARS-CoV-2 virus was first reported from Wuhan, China, on 31 December 2019. Upon study, it has been used molecular docking to binding affinity between COVID-19 protease enzyme and flavonoids with evaluations based on docking scores calculated by AutoDock Vina. Results showed that naringin suppressed COVID-19 protease, as it has the highest binding value than other flavonoids including quercetin, hesperetin, garcina and naringenin. An important finding in this study is that naringin with neighboring poly hydroxyl groups can serve as inhibitors of COVID-19 protease bind to the S pocket of protein, it is shown that residues His163, Glu166, Asn142, His41and PHe181 participate in the hydrogen bonding and pi-pi interactions, the same as happened with decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors.In other hand, some of the known protease inhibitors and anti-influenza drugs docked with COVID-19 protease, it has low binding value than naringin.

【 授权许可】

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