Fabrication and modal characterisation of large-area polymer membranes for acoustic micro-electromechanical systems devices

Micro & nano letters

article

Luca Camellini¹  Alberto Torin³  Asaad K. Al-mashaal¹  Graham S. Wood¹  Michael J. Newton³  Rebecca Cheung¹  Enrico Mastropaolo¹ 

[1] School of Engineering, Institute for Integrated Micro and Nano Systems, The University of Edinburgh;Politecnico di Torino;Acoustics and Audio Group, Edinburgh College of Art, The University of Edinburgh

关键词: aluminium;    polymer electrolytes;    vibrations;    vibration measurement;    microactuators;    measurement by laser beam;    microfabrication;    acoustic devices;    sacrificial layer;    substrate holders;    thickness ratios;    modal behaviour;    laser Doppler vibrometry;    second degenerate modes;    fifth degenerate modes;    mass density;    modal characterisation;    large-area polymer membranes;    microelectromechanical systems devices;    wet transfer technique;    polydiallyldimethylammonium chloride;    electro-thermal actuation;    PDAC;    acoustic microelectromechanical systems devices;    bilayer polymer-metal suspended membranes;    poly(methyl methacrylate);    polyelectrolyte;    PMMA-aluminum layers;    vibration detection;    nonuniform tension;    vibration amplitudes;    electric current path control;    Al;    size 3.5 mm to 400 nm;    frequency 2.0 kHz to 25.0 kHz;   

DOI  :  10.1049/mnl.2018.0089

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Breast cancer (BC) is the most commonly diagnosed cancer in women. The metabolism of iron is closely regulated by hepcidin which exerts its action by interacting with a ferroportin.  The aim of the present study was to assess the alterations in the levels of some serum biomarkers that have a role in iron homeostasis (hepcidin and ferroportin) in addition to hematological parameters (hemoglobin, leukocyte and platelets count) in different stages of BC. This study included 66 women with BC. The patients were categorized as follows : group 1 includes :22 patients with stage I disease ,group 2 includes: 22 patients with stage II disease ,and group 3 include: 22 patients with stage III disease .Group 4 includes :22 apparently healthy women as control. Data analysis revealed a significant elevation of serum hepcidin levels of patients groups 1, 2, and 3 (437.2±26.4, 501.4±31.8 and 558.5±21.3 pg/ml respectively) ,vs  (179.4±19.8 pg/ml) of control, with  steady elevations from stage I to III . Furthermore, serum ferroportin levels were significantly lowered in groups 1 and 3 compared to control  (0.589±0.107  and 0.733±0.1 vs 1.37±0.28 ng/ml respectively).While  blood hemoglobin level of group 3 were lower (11.96±0.18 vs  12.7±0.13g/dl ) compared with controls . Blood leukocyte count of patients (all groups) (7.39±0.28 ,8.93±0.48,9.86±0.52 (^103/µl) respectively) were markedly increased compared to controls (6.06±0.23), while mean platelet count for patients in group 2&3 were significantly increased compared to controls  (313.9±19.3,309.2±25.3 vs 233.3±9.1 respectively). In conclusion, hepcidin, ferroportin and hematological markers including hemoglobin, WBC count and platelets count are altered in women with BC compared to healthy control. The changes occur mostly in accordance with disease stages.

【 授权许可】

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