Li 4 Ti 5 O 12 /Ti 4 O 7 /carbon nanotubes composite anode material for lithium-ion batteries

Micro & nano letters

article

Xiaoyan Zhang¹  Wen Xu²  Xing Li²  Xiaoxi Zhong³  Wanying Liu²  Yuanhua Lin¹  Ruochen Xia⁴ 

[1] State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation (Southwest Petroleum University);School of Materials Science and Engineering, Southwest Petroleum University;Sichuan Province Key Laboratory of Information Materials and Devices Application, Chengdu University of Information Technology;PetroChina Southwest Oil & Gasfield Company

关键词: lithium compounds;    titanium compounds;    carbon nanotubes;    nanocomposites;    secondary cells;    electrochemical electrodes;    nanofabrication;    electrochemical analysis;    electrochemistry;    electrical conductivity;    charge exchange;    nanotube devices;    Li4Ti5O12-Ti4O7-C;    temperature 20 degC;    electron transfer;    electronic conductivity;    electrodes;    cycle stability;    spinel;    electrochemical tests;    LIB;    CNT;    lithium-ion batteries;    composite anode material;    carbon nanotubes;   

DOI  :  10.1049/mnl.2017.0799

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Nebivolol (NBH) is a third-generation B1-blocker with high selectivity and vasodilation activity. Nevertheless, nebivolol exhibits low oral bioavailability, which may adversely affect its efficacy. Recently, supersaturable self-nanoemulsion (Su-SNE) is an advanced SNE approach that can address low bioavailability The study aims to prepare nebivolol-loaded Su-SNE by reduction the amount of the prepared conventional SNE to half. Besides, an appropriate polymer type and concentration to prevent NBH precipitation upon oral administration have investigated.. A conventional self-nanoemulsion (formula A) was prepared by dissolving NBH in 500 mg vehicle mixture of imwitor®988: cremophor-EL: propylene glycol. Then, eight Su-SNE formulas with the absence or presence of four different polymers were prepared and evaluated. In-vitro precipitation assay was performed to assess the precipitation inhibition capacity of polymers. The ex-vivo permeation through rat intestinal mucosa was also conducted for determination of permeability parameters. Results revealed that (Su-SNA formula SAS1) containing 5% soluplus could effectively retard the nebivolol precipitation. There was no statistical difference between formula A and SAS1; both maintained a higher apparent NBH concentra­tion for approximately 240 min in 0.1N HCl. The permeation rate of conventional (formula A) and soluplus-based Su-SNE (formula SAS1) was significantly improved, and the permeation enhancement ratio was found 2.7 and 3.2, respectively, as compared with non-formulated NBH. Consequently, it is concluded that developing soluplus-based nebivolol SNE is a promising alternative approach. It can enhance nebivolol stability and permeability with half the amount of conventional SNE components.

【 授权许可】

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