Reversible lossless manipulation of water droplets with large-range volume

Micro & nano letters

article

Liu Huang¹  Xuyue Wang¹  Changlin Zhao¹  Jiyu Liu¹  Ziai Liu¹  Yankui Sun¹  Xin Liu¹  Jinlong Song¹ 

[1] Key Laboratory for Precision and Non-Traditional Machining Technology of the Ministry of Education, Dalian University of Technology;Collaborative Innovation Center of Major Machine Manufacturing in Liaoning, Dalian University of Technology

关键词: water;    drops;    two-phase flow;    pipe flow;    hydrophobicity;    etching;    electrochemistry;    contact angle;    capillarity;    reversible lossless manipulation;    water droplets;    microdroplets;    liquid transportation;    superhydrophobic surfaces;    adhesion;    transfer pipette;    superhydrophobic hole;    pressure-generation device;    electrochemical etching;    boiling-water immersion;    stearic acid modification;    water contact angle;    roll-off angle;    capillary force;    gravity;    biological field;    microfluidic field;    H2O;   

DOI  :  10.1049/mnl.2017.0789

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Piroxicam (PIR) is a nonsteroidal anti-inflammatory drug of oxicam category, used in gout, arthritis, as well as other inflammatory conditions (topically and orally). PIR is practically insoluble in water, therefore the aim is prepare and evaluate piroxicam as liquid self-nanoemulsifying drug delivery system to enhance its dispersibility and stability. The Dispersibilty and Stability study have been conducted in Oil, Surfactant and Co-surfactant for choosing the best materials to dissolve piroxicam. The pseudo ternary phase diagrams have been set at 1:1, 2:1, 3:1 as well as 4:1 ratio of surfactants and co-surfactants, also there are 4 formulations were prepared by using various concentrations of transcutol HP, cremophore EL and triacetin oil. All the constructed prepared formulas have been assessed for in vitro drug dissolution, thermodynamic stability, polydispersity index, robustness to dilution, particle size distribution, drug content, and the dispersibility and emulsification time.From the presented research concluded that the self-nanoemulsifying drug delivery system is the convenient method for improving Dispersibilty and Stability of piroxicam.  Keywords: Pseudo-ternary phase diagram, Dissolution rate, SNEDDS, Piroxicam.

【 授权许可】

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