Microstructural behaviour and flowing ability of self-compacting concrete using micro- and nano-silica

Micro & nano letters

article

Nandhini K¹  Ponmalar V¹ 

[1] Department of Civil Engineering, Anna University

关键词: concrete;    cements (building materials);    structural engineering;    silicon compounds;    nanostructured materials;    construction industry;    carbon compounds;    air pollution;    microstructural behaviour;    flowing ability;    self-compacting concrete;    nanosilica;    construction material;    negative environmental issue;    cement production;    ground granulated blast-furnace slag;    microsilica;    silica content;    material characterisation techniques;    particular substitute material;    Concrete guidelines;    carbon dioxide contribution;    building industry;    structural composition;    time 28.0 d;   

DOI  :  10.1049/mnl.2018.0105

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Cyclophosphamide is chemotherapeutic agent that utilized for the treatment of different malignancies; however its’ used associated with numerous adverse effects. Vitamin B2 and vitamin B12 suggested having myeloprotective effect. This work is designed to investigate the myeloprotective effect of both vitamins against cyclophosphamide induced myelosuppression. One hundred adult rats of both sexes were used in this study. The animals were randomly enrolled into ten groups of 10 rats each. Group I: Control group. Group II: Cyclophosphamide-treated. Group III and Group IV Orally-administered vitamin B2 (10, and 40 mg/kg/day), respectively alone for 7 days. Group V: Orally-administered vitamin B12 (0.1 mg/kg/day) alone for 7 days. Group VI and Group VII: Orally-administered vitamin B2 (10, and 40 mg/kg/day), respectively for 7 days and a single IP injection of cyclophosphamide (150 mg/kg) at day 7.Group VIII: Orally-administered vitamin B12 (0.1 mg/kg/day) for 7 days and a single IP injection of cyclophosphamide (150 mg/kg) at day 7. Group IX: Orally-administered a combination of vitamin B2 (10 mg/kg/day) and vitamin B12 (0.1 mg/kg/day) for 7 days and a single IP injection of cyclophosphamide (150 mg/kg) at day 7. Group X: orally-administered a combination of vitamin B2 (40 mg/kg/day) and vitamin B12 (0.1 mg/kg/day) for 7 days and a single IP injection of cyclophosphamide (150 mg/kg) at day 7. On day eight, animals were sacrificed and blood collected for CBCs and femur bone were extracted for bone marrow histological examination. Vitamin B2 and vitamin B12 significantly (P<0.05) increase CBCs; and the combination of vitamins produce -a significant (P<0.05) increase in CBCs compared to corresponding counts in other Groups, and -improve histopathological changes compared to Group II rats. In conclusion both vitamins may have myeloprotective effects against cyclophosphamide-induced myelosuppression.

【 授权许可】

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