期刊论文详细信息
Micro & nano letters
Molybdenum gratings as a high-temperature refractory platform for plasmonic heat generators in the infrared
article
Sara Nunez-Sanchez1  Hugo Dominguez Andrade3  Jan Harwood3  Ian Bickerton3  Neil A. Fox3  Martin J. Cryan1 
[1] Department of Electrical and Electronic Engineering, Faculty of Engineering, University of Bristol, University Walk;Universidade de Vigo;School of Chemistry, CVD Diamond Group, University of Bristol
关键词: diffraction gratings;    polaritons;    plasmonics;    molybdenum;    milling;    refractories;    surface plasmons;    optical couplers;    temperature measurement;    optical films;    laser beam machining;    light absorption;    gas lasers;    light sources;    optical properties;    plasmonic couplers;    laser milling;    real-time absolute temperature measurements;    plasmonic heat generators;    heating efficiency;    surface plasmon polaritons;    metal grating couplers;    molybdenum films;    industrial refractory metal;    laser light source;    linear molybdenum gratings;    high-temperature refractory microstructures platform;    absorption;    size 10.6 mum;    temperature 702.0 K to 985.0 K;    Mo;   
DOI  :  10.1049/mnl.2018.0156
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

The aim of the present study is to formulate floating effervescent microsponge tablet of the narrow absorption window drug, Baclofen (BFN) for controlling drug release and thereby decrease the side effect of the drug. The microsponges of BFN were prepared by non-aqueous emulsion solvent diffusion method (oil in oil emulsion method). The effects of drug: polymer ratio, stirring time and type of Eudragit polymer  on the physical characteristics of microsponges were investigated and characterized for production yield, loading efficiency, particle size, surface morphology, and in vitro drug release from microsponges. The selected microsponge formula was incorporated into the floating effervescent gastro-retentive tablet. The prepared floating microsponge tablet was evaluated for tablet hardness, friability, swelling in addition to in vitro drug release. The results showed that the microsponge formula with Eudragit RS100 had optimum physical properties and controlled drug release (75% of drug release in 8 hr.) when compared with other formulas and pure baclofen. The oil in oil emulsion method is a promising method to produce baclofen microsponge.

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CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND   

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