期刊论文详细信息
Micro & nano letters
Power generation from microfluidic drops using inorganic silicon dioxide electret film
article
Jianxiong Zhu1  Hai Wang2 
[1] Beijing Institute of Nanoenergy and Nanosystems, Chinese Academy of Sciences, National Center for Nanoscience and Technology (NCNST);School of Energy and Power Engineering, Jiangsu University
关键词: electrets;    energy harvesting;    microfluidics;    drops;    silicon compounds;    semiconductor thin films;    power generation;    microfluidic drops;    inorganic silicon dioxide electret film;    microfluidic structure;    damping motion;    microfabricated electret silicon oxide;    instantaneous acceleration;    variable shape;    damped wave phenomena;    inertial forces;    open-circuit voltage;    linear equation;    quadratic equation;    microfluidic energy harvester;    short-circuit current;    voltage 0.18 V;    current 3.0 nA;    voltage 0.3 V;    SiO2;   
DOI  :  10.1049/mnl.2018.5090
学科分类:计算机科学(综合)
来源: Wiley
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【 摘 要 】

Abstract:        The aim of the current study was to investigate the possible protective effect of graded doses (5, 10, and 15mg/kg) of pyridoxine hydrochloride intraperitoneally injected against (15mg/kg) doxorubicin-induced cardiotoxicity in female rats. Fifty-six (56) Wistar albino female rats were utilized weighing 180-200 gm allocated into eight groups, seven rats each; Group I: negative control distilled water; Group II: Pyridoxine (5mg/kg); Group III: Pyridoxine (10mg/kg); Group IV: Pyridoxine (15mg/kg); Group V: doxorubicin (15 mg/kg); Group VI: Pyridoxine (5 mg/kg) prior to doxorubicin (15 mg/kg); Group VII: Pyridoxine (10 mg/kg) prior to doxorubicin (15 mg/kg); Group VIII: Pyridoxine (15 mg/kg) prior to doxorubicin (15 mg/kg). DOX caused significant elevations in serum biomarker enzymes of aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and significant reduction in heart tissue homogenate content of total antioxidants capacity (TAOC). Treatment with 15mg/kg pyridoxine for four consecutive days prior to a single dose 15mg/kg doxorubicin resulted in significant reduction in serum enzymes level of AST and LDH. Treatment with 10 or 15mg/kg pyridoxine for four consecutive days prior to a single dose of doxorubicin produced significant increments in TAOC heart tissue homogenate level compared to positive control. In conclusion, pyridoxine supplementation might be a promising adjunctive agent for improving oxidative stress and biological markers for preventing DOX-induced cardiac complications.

【 授权许可】

CC BY|CC BY-ND|CC BY-NC|CC BY-NC-ND   

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