Facile design and fabrication of capillary valve for mixing using two-step PDMS moulding

Micro & nano letters

article

Chia-Chun Lai¹  Chen-Kuei Chung¹ 

[1] Department of Mechanical Engineering, National Cheng Kung University

关键词: hydrophilicity;    photolithography;    polymers;    microfluidics;    wetting;    hydrophobicity;    lab-on-a-chip;    capillarity;    ageing;    numerical analysis;    contact angle;    plasma materials processing;    moulding;    mixing;    bubbles;    design engineering;    channel flow;    valves;    flow control;    laser ablation;    carbon compounds;    oxygen;    polydimethylsiloxane mixing channel;    facile delay valve;    open surface design;    long-term-hydrophilic capillary-pumping;    hydrophobic PDMS;    capillary valve fabrication;    numerical analysis;    two-step moulding process;    photolithography;    CO2 laser-ablated PMMA mould;    polyethylene glycol;    O2 plasma treatment;    contact angle aging measurement;    clogging;    size 150.0 mum;    size 250.0 mum;    time 164.0 hour;    O2;    CO2;   

DOI  :  10.1049/mnl.2018.5067

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Ondansetron hydrochloride (ONH) is a very bitter, potent antiemetic drug used for the treatment and/or prophylaxis of chemotherapy or radiotherapy or postoperative induced emesis. The objective of this study is to formulate and evaluate of taste masked fast dissolving tablet (FDTs) of ONH to increase patient compliance.  ONH taste masked granules were prepared by solid dispersion technique using Eudragit E100 polymer as an inert carrier. Solvent evaporation and fusion melting methods were used for such preparation. Completely taste masking with zero release of drug in phosphate buffer pH 6.8was obtained from granules prepared by solvent evaporation method using drug: polymer ratio of 1:2, from which four formulas pass pre-compression evaluation and compressed to FDTs and evaluated for their drug content, in-vitro disintegration time, in-vivo disintegration time, wetting time and in vitro drug release profile. F7 which is prepared from solid dispersion product equivalent to the required dose of ONH  , Crosspovidone as superdisintegrant, Aspartame as sweetener ,Ross berry as flavor ,Polyvinylpyrolidone K30.3.as binder ,Avicil PH102 and , mannitol as diluents give best in- vitro, in-vivo disintegration time and best drug release profile.

【 授权许可】

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