Effect of precipitated phase on dislocation activity under high-frequency impacting and rolling

Micro & nano letters

article

Huijing Zhang¹  Xiaoming Qiu¹  Desheng Xu¹  Yu Liu²  Xiaohui Zhao¹ 

[1] Key Laboratory of Automobile Materials, School of Materials Science and Engineering, Jilin University;School of Mechanical Science and Engineering, Jilin University

关键词: deformation;    slip;    transmission electron microscopy;    aluminium alloys;    silicon alloys;    precipitation;    magnesium alloys;    grain refinement;    dislocation activity;    high-frequency impacting;    transmission electron microscopy;    coordinated deformation dislocation mechanism;    dislocation motion;    high-frequency rolling;    crystal microstructures;    slip;    grain refinement;    precipitated phase;    Al-Mg-Si;   

DOI  :  10.1049/mnl.2018.5074

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

The aim of this study is to formulate and evaluate ezetimibe nanoparticles using solvent antisolvent technology. Ezetimibe is a practically water-insoluble drug which acts as a lipid lowering drug that selectively inhibits the intestinal absorption of cholesterol and related phytosterols. Ezetimibe prepared as nano particles in order to improve its solubility and dissolution rate. Thirty formulas were prepared and different stabilizing agents were used with different concentrations such as poly vinyl pyrrolidone (PVPK-30), poly vinyl alcohol (PVA), hydroxy propyl methyl cellulose E5 (HPMC), and poloxamer. The ratios of drug to stabilizers used to prepare the nanoparticles were 1: 2, 1:3 and 1:4. The prepared nanoparticles were evaluated for particle size, entrapment efficiency, dissolution study, Fourier transform infrared spectroscopy, differential scanning calorimetry, and atomic force microscopy. The percentage of drug entrapment efficiency of F1-F30 was ranged from 85% ± 1 to 98 % ± 1. On the other hand dissolution rate increasing as the particle surface area is increase due to reduction of particle size to the nano range. The results showed that poly vinyl pyrrolidone (PVPK-30) was found to be the best stabilizer.  Keywords: Ezetimibe, Nanoparticles, Particle Size, poly vinyl alcohol.

【 授权许可】

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