High temperature high sensitivity optical fibre sensor based on multimode fibre Bragg grating

Micro & nano letters

article

Qijing Lin¹  Na Zhao¹  Weile Jiang⁵  Kun Yao¹  Bian Tian¹  Peng Shi⁶  Feng Chen¹ 

[1] State Key Laboratory for Manufacturing Systems Engineering, Xi'an Jiaotong University;Collaborative Innovation Center of High-End Manufacturing Equipment, Xi'an Jiaotong University;State Key Laboratory of Digital Manufacturing Equipment & Technology, Huazhong University of Science and Technology;State Key Laboratory of Fluid Power and Mechatronic Systems, Zhejiang University;Institute of Heritage Sites & Historical Architecture Conservation, Xi'an Jiaotong University;Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, School of Electronic and Information Engineering, Xi'an Jiaotong University

关键词: Bragg gratings;    fibre optic sensors;    temperature measurement;    electromagnetic wave interference;    high temperature high sensitivity optical fibre sensor;    multimode fibre Bragg grating;    multiple reflection peaks;    lead-out fibre core;    temperature sensitivity;    MMFBG;    bounded modes;    spatial frequency spectra;    transmission spectrum;    antielectromagnetic interference;    stable chemical property;    temperature measurement;    compact structure;   

DOI  :  10.1049/mnl.2018.5233

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Nystatin is the drug of choice for treatment of cutaneous fungal infections with main disadvantage that is the need for multiple applications to achieve complete eradication which may reduce patient compliance. Microparticles offer a solution for such issue as they are one of sustained release preparations that achieve slow release of drug over an extended period of time. The objectives of this study were to fabricate nystatin-loaded chitosan microparticles with the ultimate goal of prolonging drug release and to analyze the influence of polymer concentration on various properties of microparticles. Microparticles were prepared by chemical cross-linking method using glutaraldehyde as cross-linking agent. Five formulas, namely N1C1, N1C2, N1C3, N1C4 and N1C5, were prepared and the effect of drug to polymer ratio was studied with respect to drug loading, encapsulation efficiency, particle size and morphology. Furthermore the prepared microparticles were subjected to various physico-chemical studies, such as drug- polymer compatibility by Fourier Transform Infrared Spectroscopy (FTIR) and in-vitro drug release characteristics. Microparticles obtained from N1C1, N1C2 and N1C3 formulas were regular in shape with mean particle size ranging between 1µm and 10µm. N1C5 formula was resulted in particles with irregular shape while N1C4 showed a blend of microparticles and deformed particles. The effect of chitosan concentration on drug loading and entrapment efficiency was studied. The results showed increment in these parameters that was directly proportional to the increment in polymer concentration. Percentage yield showed a significant increment which was related to the increment in the ratio of chitosan used during the study. FTIR results showed no interactions between nystatin and chitosan. DSC studies proved the crystalline nature of nystatin and chitosan. On other hand, the thermogram of loaded microparticles showed the absence of endothermic peak corresponding to nystatin which may indicate the loss of the crystalline nature of the drug presented inside the microparticles. In- vitro release studies resulted in 95.6% release of nystatin for N1C1 after 15 hours. N1C1 appeared to be promising in formulating microparticles that provide nearly complete release of the drug within15 hours. This formula can be selected in future work to be formulated as topical gel that prolongs the release of nystatin.

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