Stable temperature characteristic of phosphate glass ceramic for white light-emitting diode

Micro & nano letters

article

Xiaobin Ren¹  Manting Pei¹  Chengguo Ming¹  Aihua Zhou³  Dandan Ju³  Feng Song³ 

[1] Physics Department, School of Science, Tianjin University of Science & Technology;School of Material Science and Chemical Engineering, Tianjin University of Science & Technology;The Key Laboratory of Weak Light Nonlinear Photonics, Ministry of Education, Nankai University

关键词: annealing;    nanofabrication;    phosphate glasses;    quenching (thermal);    thermal stability;    phosphors;    light emitting diodes;    glass ceramics;    melting;    photoluminescence;    melt processing;    calcium compounds;    lithium compounds;    aluminium compounds;    silicon compounds;    manganese compounds;    thulium compounds;    terbium compounds;    stable temperature characteristic;    high-temperature melting method;    heat annealing technology;    strong white light;    temperature range;    phosphate glass ceramic material shows good property;    white light emitting diode;    thulium-terbium-manganese tridoped phosphate glass ceramic;    luminescence intensity;    thermal stability;    phosphor;    temperature 25 degC to 300 degC;    P2O5-CaO-Li2O-Al2O3-SiO2-MnO2-TbO2-TmO2;   

DOI  :  10.1049/mnl.2018.5339

学科分类：计算机科学（综合）

来源: Wiley

【 摘 要 】

Clotrimazole (CLO) is an antimycotic imidazole derivative applied locally for the treatment of vaginal yeast infections. In this study, CLO was formulated as vaginal mucoadhesive hydrogel, using different types of mucoadhesive polymers to ensure prolonged contact between active ingredient and vaginal mucosa. Physicochemical properties of the prepared formulas were evaluated as a visual inspection, pH, swelling index, spreadability, and mucoadhesive characteristics, in addition to an in-vitro drug release. The influence of type and concentration of polymers as CMC-Na (1.5, 2.5, and 3.5%w/w), carbopol 940( 0.25, 0.5, and 1 %w/w) and poloxamer 407 (15, 25, 30%w/w) on CLO release  from the prepared gels were also investigated. All the different concentrations of each polymer gave a percent of drug release profile inversely proportional with the polymer concentration. The lowest concentration showed faster release within the first half an hour  of 99± 2% of drug release , while CMC-Na at 3.5% (F2) demonstrated the least release of 40 % after three hours. On the other hand, poloxamer 407 of 25% gel (F7) produced the highest release of 98%, while carbopol 1% (F5) and CMC-Na (F1) produced 85% and 80% ,respectively. All the prepared formulas were following Higuchi kinetic model. Based on overall result, CLO can be formulated as mucoadhesive vaginal hydrogel using 25%poloxamer as the best prepared formula.

【 授权许可】

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